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Quantitative CT-defined mucus plugs combined with emphysema severity stratify COPD patients into distinct subtypes that predict risk of acute exacerbations, enabling personalized risk assessment and targeted preventive strategies.
This review synthesizes recent evidence on quantitative CT markers of mucus plugging and emphysema in COPD, highlighting their combined impact on acute exacerbation risk and clinical heterogeneity, and discusses implications for personalize
The 2026 international report redefines acute exacerbation across fibrotic interstitial lung diseases, proposes a framework to separate AE from other acute respiratory worsenings, and sets priorities for diagnosis, treatment, trial design,