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Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort
GastroenterologyAcute-on-chronic liver failureAlcohol-Associated Hepatitis

Metabolic Dysfunction Did Not Worsen Short-Term Survival in Severe Alcohol-Associated Hepatitis in a Global Prospective Cohort

By MedXY|May 26, 2026

In a 32-center international cohort, cardiometabolic risk factors were common in alcohol-associated hepatitis but did not independently increase 180-day mortality after adjustment for liver disease severity and competing transplant risk.

Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure
Critical CareAcute liver failureAcute-on-chronic liver failure

Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure

By MedXY|Oct 28, 2025

The UTOpiA system, integrating HLA-depleted iPSC-derived liver organoids with granulocyte-monocyte apheresis, significantly improves survival and liver regeneration in acute-on-chronic and acute liver failure rat models, representing a prom

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