SAFE Score (Steatosis-Associated Fibrosis Estimator)
The SAFE score was specifically engineered for primary care and community medicine settings to overcome the major clinical limitations of legacy non-invasive scores (such as FIB-4, APRI, and NFS), which frequently yield large indeterminate intermediate gray zones (30% to 50%) and possess suboptimal sensitivity for early significant fibrosis (stage >= F2)
Demographics & Metabolic Profile
Assess patient age, body mass index (BMI), and type 2 diabetes status
Patient chronological age in years
Weight in kg divided by height in meters squared (capped at 40 kg/m² in calculation)
Established diagnosis of type 2 diabetes mellitus
Routine Laboratory & Hematology
Enter transaminases, serum globulin, and platelet count
Serum aspartate aminotransferase concentration (U/L)
Serum alanine aminotransferase concentration (U/L)
Calculated as total serum protein minus albumin (Total Protein - Albumin); standard unit is g/dL (g/L is automatically converted)
Complete blood count platelet concentration (supports 10⁹/L, 10³/µL, or /µL)