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Drug Interaction Probability Scale (DIPS)

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Drug Interaction Probability Scale (DIPS)

Estimates the probability that a suspected drug interaction is causal.

Answer according to the patient’s medication exposure and available clinical evidence.

Assessment

1. Are there previous credible reports of this interaction in humans?

2. Is the interaction consistent with the pharmacologic properties of the precipitant drug?

3. Is the interaction consistent with the pharmacologic properties of the object drug?

4. Is the timing compatible with administration of the two drugs?

5. Did the interaction lessen after the precipitant drug was stopped?

6. Did the interaction recur when the precipitant drug was readministered?

If the precipitant drug was not stopped in question 5, choose unknown.

7. Are there alternative causes that could explain the event?

8. Did object-drug concentrations change in a manner consistent with the interaction?

9. Is there other objective evidence supporting the interaction?

10. Is the interaction dose-response related to the precipitant drug?

Please complete all required fields first.

Important Notice

This resource is intended for educational purposes only and is intended for US healthcare professionals. Healthcare professionals should use independent medical judgment. All decisions regarding patient care must be handled by a healthcare professional and be made based on the unique needs of each patient.